Toxic Megacolon leading to bowel perforation: A rare adverse effect of bortezomib

Toxic megacolon: the knee-elbow position relieves bowel distension.

Toxic megacolon complicating inflammatory or infective colitis carries a high morbidity and mortality and surgical intervention is necessary in up to 80% of cases. Perforation complicates toxic megacolon in about 35% of cases. After perforation, the death rate nears 50%. Gaseous distension of the bowel causes considerable discomfort to the patient and increases transmural pressure. The latter i...

Toxic megacolon with late perforation in Campylobacter colitis--a cautionary tale.

Toxic megacolon in cryptosporidiosis.

A 33 year old man with acquired immunodeficiency syndrome developed a toxic megacolon. The patient was admitted with a two month history of diarrhoea. Cryptosporidia were isolated from all stool specimens. Clinically and radiographically he developed toxic dilatation of the colon which responded to conservative management.

Neonatal Intestinal Perforation—A Rare Complication of Small Bowel Hemangioma

Intestinal perforation is an extremely rare complication of hemangioma of the small intestine in the neonatal period. This is a case report of a 27-days-old male infant who presented with signs and symptoms of acute intestinal obstruction. Exploratory laparotomy findings revealed intestinal perforation due to solitary hemangioma in the ileum, which led to obstruction from peritoneal reaction an...

Small bowel perforation: a rare complication of ventriculoperitoneal shunt placement.

Small bowel perforation is a rare complication of ventriculoperitoneal (VP) shunt placement. When seen, it most commonly affects the stomach or colon. We describe a case and image findings of an 8-year-old female who presented with sepsis and erosion of the VP shunt into the small bowel. The imaging findings were confirmed surgically. We also provide an overview of the current literature discus...